Stem Cell Reports Article Transiently Active Wnt/b-Catenin Signaling Is Not Required but Must Be Silenced for Stem Cell Function during Muscle Regeneration
نویسندگان
چکیده
Malea M. Murphy,1,2,3 Alexandra C. Keefe,1,2 Jennifer A. Lawson,1 Steven D. Flygare,1 Mark Yandell,1 and Gabrielle Kardon1,* 1Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA 2Co-first author 3Present address: Children’s Research Institute at UT Southwestern, Dallas, TX 75390, USA *Correspondence: [email protected] http://dx.doi.org/10.1016/j.stemcr.2014.06.019 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
منابع مشابه
Transiently Active Wnt/β-Catenin Signaling Is Not Required but Must Be Silenced for Stem Cell Function during Muscle Regeneration
Adult muscle's exceptional capacity for regeneration is mediated by muscle stem cells, termed satellite cells. As with many stem cells, Wnt/β-catenin signaling has been proposed to be critical in satellite cells during regeneration. Using new genetic reagents, we explicitly test in vivo whether Wnt/β-catenin signaling is necessary and sufficient within satellite cells and their derivatives for ...
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